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Professor David Vaux

Professor David Vaux

Sub-Rector, Nuffield Research Fellow in Pathology and Tutorial Fellow in Medicine

Academic Profile
I took my first degree in physiological sciences at Corpus Christi College, Oxford and was then a postgraduate in the Dunn School of Pathology where I obtained a doctorate for research into macrophage physiology under the supervision of Professor Siamon Gordon.

After completing my medical training in Oxford, I left clinical medicine and spent several years in the Department of Cell Biology at Yale University working on monoclonal network antibodies as reagents to study intracellular protein sorting. In 1988 I moved to Germany and established an independent cell biology research group at the European Molecular Biology Laboratories in Heidelberg. I came to Lincoln in 1991.

I teach pathology, immunology and genetics to medical students, and cell and molecular biology to medics, physiologists and biochemists.

Research Interests

My research interests are centred on the relationship between human disease and proteins altered by post-translational modifications, proteolytic processing or aberrant folding. A wide variety of experimental techniques are used, extending from protein chemistry, mass spectrometry, planar bilayer electrophysiology and microarray analysis through to a range of digital imaging techniques at the light and electron microscope level. Specific topics of current interest include:

Research Details

  • Laminopathies and dynamic structural defects in the nuclear envelope
  • Extranuclear roles of BRCA1 in mitochondrial DNA repair and cell motility
  • Acetylcholinesterase in the pathogenesis of Alzheimer's disease
  • Peptide membrane insertion and pathological channel formation as mechanisms of neurotoxicity
  • MAPS (multimer analysis of phage sequences) for characterisation of complex surfaces

 

Recent Publications (2005-)
Coene E, Hollinshead MS, Waeytens A, Schelfhout V, Eechaute W, Van Oostveldt P and Vaux DJ (2005) "Phosphorylated BRCA1 is predominantly located in the nucleus and in mitochondria" Mol Biol Cell 16 997-1010

 

Kail M, Hollinshead M, Kaufmann M, Boettcher J, Vaux DJ, Barnekow A. (2005) "Yeast Ypt11 is targeted to recycling endosomes in mammalian cells" Biol Cell 97651-8.

Tunnah D, Sewry CA, Vaux DJ, Schirmer EC, Morris GE (2005) "The apparent absence of lamin B1 and emerin in many tissue nuclei is due to epitope masking" J Mol Histol 36 337-44.

Malhas, A, Lee C-F, Sanders R, Saunders NJ and Vaux DJ (2007) "Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression" J Cell Biol 176 593-603.

Jean, L, Thomas, B, Tahiri-Alaoui, A, Shaw, MK, Vaux DJ (2007) "Heterologous Amyloid Seeding: Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease". PLoS ONE 2(7): e652. doi:10.1371/journal.pone.0000652

Coene, ED, Shaw, MK and Vaux, DJ (2008) "Anti-biotin antibodies for specific mitochondrial labelling" Methods Mol Biol. 418 157-70.

Jean L, Lee CF, Shaw M, and Vaux DJ.(2008)" Structural elements regulating amyloidogenesis: a cholinesterase model system". PLoS ONE. 2008 Mar 19;3(3):e1834

Malhas, AN, Lee, CF, and Vaux DJ. (2009) "Lamin B1 controls oxidative stress responses via Oct-1". J Cell Biol. 184 45-55

Malhas AN, Vaux DJ (2009) "Transcription factor sequestration by nuclear envelope components." Cell Cycle. 8 959-60

Lee CF, Loken J, Jean L and Vaux DJ (2009) "Elongation dynamics of amyloid fibrils: A rugged energy landscape picture" Physical Review E EZ10468 Lee

Jean L, Lee CF, Lee C, Shaw M and Vaux DJ (2009)  "Competing discrete interfacial effects are critical for amyloidogenesis" FASEB J doi: 10.1096/fj.09-137653

Goulbourne C, Malhas AN and Vaux DJ (2010) "HIV Protease Inhibitors Inhibit FACE1 /ZMPSTE24: A Mechanism for Acquired Lipodystrophy in Patients on Highly Active Anti Retroviral Therapy?" Biochem Soc Trans 38  292-6

Malhas AN, Saunders NJ and Vaux DJ (2010) "The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation." Cell Cycle. 2010 Feb 3; 9. [Epub ahead of print] PMID: 20081371  

Martin N, Welsch S, Jolly C, Briggs JAG, Vaux DJ and Sattentau QT (2010) "Virological Synapse-Mediated Spread of Human Immunodeficiency Virus Type-1 between T cells is Sensitive to Entry Inhibition" J Virol doi:10.1128/JVI.02651-09



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